4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine) is a synthetic tryptamine structurally related to psilocin and other 4-hydroxylated indole derivatives. It has been included in analytical and forensic surveys of emerging tryptamines, particularly where laboratories require reliable reference materials to confirm identity in complex mixtures.
In research settings, 4-HO-MET is often considered alongside related compounds for comparative studies of:
• LC-MS and GC-MS fragmentation patterns within the 4-hydroxy tryptamine family;
• Chromatographic retention behavior under varying mobile phases and stationary phases;
• Stability of hydroxyindole derivatives under different storage and processing conditions.
Handling And Storage
• Store in a cool, dry environment, protected from direct light and moisture.
• Keep container tightly closed when not in use to minimize environmental exposure.
• Use appropriate PPE (gloves, eye protection, lab coat) during handling and weighing.
• Limit repeated freeze–thaw cycles where applicable to reduce potential degradation.
• Dispose of unused material and waste according to local regulations for chemical substances.
Always follow your institution’s internal safety guidelines and risk assessments when working with analytical reference materials.




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