1cP‑LSD (1‑cyclopropanoyl‑lysergic acid diethylamide) is a semi‑synthetic lysergamide bearing a cyclopropanoyl group at the indole nitrogen (N¹ position). It has the molecular formula C₂₄H₂₉N₃O₂ and a freebase molar mass of approximately 391.5 g·mol⁻¹.
Emerging around 2019, 1cP‑LSD belongs to the same N¹‑acyl lysergamide family as 1P‑LSD, 1B‑LSD, 1V‑LSD, and ALD‑52. It has been the subject of detailed analytical characterization, including:
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LC–MS(/MS) and LC–HRMS for mass‑spectral and fragmentation profiling,
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GC–MS for comparison with other lysergamides and assessment of potential deacylation,
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Chromatographic method development and retention‑time comparison across lysergamide panels,
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Structural confirmation by NMR and complementary spectroscopic techniques.
In research and casework, 1cP‑LSD is typically included in lysergamide panels used to study:
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Fragmentation patterns and exact‑mass data across N¹‑acyl analogues,
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Chromatographic separation and selectivity in multi‑analyte methods,
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Stability and potential N¹‑deacylation pathways under various storage and analytical conditions.
These properties make 1cP‑LSD a useful reference point when differentiating between closely related lysergamides in seized‑material and toxicological investigations.




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