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JTE-907 is a selective CB2 receptor inverse agonist used in research to probe the role of CB2 in inflammation and immune-related processes. It has high potency in rodent systems, is moderately potent in human assays, and is used to study how reducing CB2 receptor activity affects biological outcomes. While promising as a research tool, it remains far from being a therapeutic drug itself. Buy JTE-907 Online.

• JTE-907 is a synthetic small-molecule compound whose chemical name is N-(1,3-benzodioxol-5-ylmethyl)-1,2-dihydro-7-methoxy-2-oxo-8-(pentyloxy)-3-quinolinecarboxamide.

• Its molecular formula is C₄₄? (No: C₄₄ is wrong; it is C₂₄H₂₆N₂O₆) and molecular weight ~438.48 g/mol.

• CAS number: 282089-49-0.

• It is not approved as a therapeutic drug (for human clinical use) — it is used as a research tool compound. Buy JTE-907 Online

JTE-907 For Sale

Research Uses

• Pharmacologic profile in both cell systems and animals.

• In animal studies, JTE-907 has demonstrated anti-inflammatory effects — for example in cutaneous inflammation in mice.

• Also, in models of pruritus (itching) associated with dermatitis, JTE-907 suppressed itch-associated responses in mice.

• is mainly expressed in peripheral tissues (immune cells, peripheral nerves) rather than high levels in CNS, compounds like JTE-907 help study the non-CNS cannabinoid receptor biology (immune modulation, pain, inflammation).

Mechanism of Action

• JTE-907 is described as a selective inverse agonist at the CB2 receptor (cannabinoid type 2 receptor).

• “Inverse agonist” means that it binds the receptor and reduces its basal (constitutive) activity rather than simply blocking activity (as an antagonist would). This is relevant in receptors that have constitutive signalling.

• Binding affinity data: For rat CB2 receptor Ki ≈ 0.38 nM, for mouse ≈1.55 nM, for human ≈35.9 nM (as per one supplier’s datasheet).

• It shows much weaker affinity for CB1 receptor (for human CB1 ≈2,370 nM according to one source) — demonstrating selectivity for CB2 over CB1. Buy JTE-907 Online.

• Functionally: by reducing CB2 receptor signalling, JTE-907 has been shown to modulate immune / inflammatory responses in pre-clinical models.