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5F‑AEB‑2201 (also called 5F‑EMB‑PINACA or 5F‑AEB) is a synthetic cannabinoid belonging to the indazole‑3‑carboxamide family. It has gained attention in recent years as a potent research chemical, primarily due to its activity on cannabinoid receptors and its appearance in forensic and pharmaceutical contexts. Because of its potency and potential for harm, 5F‑AEB‑2201 is a subject of increasing interest in toxicology, regulatory, and public health research. Buy 5f‑aeb 2201 Online.

This article provides a detailed overview of 5F‑AEB‑2201, including its chemical structure, pharmacological effects, toxicology, legal status, and current gaps in research. Buy 5f‑aeb 2201 Online.

Chemical Profile

IUPAC Name and Structure

• The IUPAC name of 5F‑AEB (5F‑AEB‑2201) is ethyl (1-(5‑fluoropentyl)-1H-indazole-3-carbonyl)-L-valinate.
• It features an indazole core (a nitrogen-containing bicyclic ring) linked to a valinate (amino acid derivative) via a carboxamide group. (Wikipedia)
• Its molecular formula is C20H28FN3O3.

Relation to Other Cannabinoids

• 5F‑AEB-2201 is structurally very similar to other synthetic cannabinoids like 5F‑MDMB-PINACA and other indazole-based compounds.
• According to naming frameworks (e.g., EMCDDA), it’s also known as 5F‑EMB-PINACA.

Pharmacology & Mechanism of Action

Receptor Activity

• 5F‑AEB‑2201 is a potent agonist of the cannabinoid receptors, particularly CB₁ (central) and likely CB₂ (peripheral), similar to many synthetic cannabinoids. Buy 5f‑aeb 2201 Online.
• In preclinical models, it exhibits strong binding affinity and efficacy, significantly greater than that of Δ⁹‑THC in some assays.  Buy 5f‑aeb 2201 Online.

Potency

• Animal (mouse) studies cited by the U.S. Drug Enforcement Administration (DEA) suggest it is ~20 times more potent than Δ⁹‑THC in locomotor activity assays.
• Due to this potency, even small doses may produce strong effects, increasing the risk of adverse reactions or toxicity. Buy 5f‑aeb 2201 Online.

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Legal Status & Regulation

Controlled Substance Status

• According to the DEA, 5F-AEB is classified as a Schedule I controlled substance, meaning it is considered to have a high potential for abuse and no accepted medical use in the U.S.
• The Controlled Substances Act includes positional isomers such as 5F-AEB under Schedule I, reinforcing its regulatory control. Buy 5f‑aeb‑2201 Online.

International Regulation

• According to the United Nations Office on Drugs and Crime (UNODC), 5F-EMB-PINACA (aka 5F-AEB) has been added to synthetic cannabinoid control lists in certain jurisdictions.
• In France, a decree (arrêté) from October 2019 amended the narcotics list to include substances like synthetic cannabinoids.

Research Applications

Because of its high potency and receptor specificity, 5F-AEB-2201 can serve as a valuable molecule in research contexts, including:

1. Neuroscience / Pharmacology
   • Studying CB₁ and CB₂ receptor activation, signal transduction, and downstream pathways.
   • Investigating structure–activity relationships (SAR) in synthetic cannabinoids to design safer or more selective compounds.
2. Toxicology & Safety Studies
   • In vitro cytotoxicity assays (e.g., cell viability, mitochondrial function) to assess cellular toxicity.
   • Animal models (rodents) to study acute and chronic toxic effects, behavioral changes, and organ pathology.
3. Forensic Science
   • Developing analytical methods (GC-MS, LC-MS) to detect 5F-AEB-2201 and its metabolites in biological samples (blood, urine) for toxicology screening.
   • Building reference libraries for forensic labs to identify this compound in seized materials.
4. Public Health Surveillance
   • Monitoring prevalence of 5F-AEB-2201 in “legal high” products or in synthetic cannabis blends.
   • Studying epidemiological trends, patterns of misuse, associated health outcomes, and potential harms. Buy 5f‑aeb‑2201 Online.

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