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What Is 6-APB?

6-APB, also known as 6-(2-aminopropyl)benzofuran, is a benzofuran-class research chemical that has gained attention in scientific environments for its structural similarity to entactogenic phenethylamines. First synthesized in the early 1990s, 6-APB is often studied as a potential analogue to MDMA, with researchers exploring its serotonergic and adrenergic activity. Buy 6-APB online.

Chemical Background

• Chemical Class: Benzofuran
• IUPAC Name: 1-(benzofuran-6-yl)propan-2-amine
• Molecular Formula: C11H13NO
• Molar Mass: 175.23 g/mol

6-APB exists in several research formats, including powder, crystal, or pellet form, depending on supplier availability. Scientific analyses typically focus on structure–activity relationships (SAR), binding affinity, and metabolic pathways. Buy 6-APB online.

Mechanism of Interest

Research has shown that 6-APB interacts prominently with:

• Serotonin transporters (SERT)
• Norepinephrine transporters (NET)
• Dopamine transporters (DAT)

Its pharmacological profile makes it relevant for studies involving:

• Neurotransmitter release
• Monoamine modulation
• Receptor binding patterns
  Particularly, 6-APB has been identified as a potent 5-HT2B receptor agonist, which is a key subject of ongoing research. Buy 6-APB online.

Applications in Research

Academic interest in 6-APB includes:

• Behavioral neuroscience
• Pharmacodynamics and pharmacokinetics
• Comparative analysis to classical entactogens
• Toxicology and metabolic studies

Due to its unique benzofuran ring and active amine chain, 6-APB is used as a model compound in studies exploring:

• Structure modification
• Transporter affinity variations
• Monoamine system interactions

Legal Status

Regulations vary significantly by region. In many countries, 6-APB is:

• Controlled or regulated,
• Classified under analogue laws, or
• Restricted for laboratory use only.

Researchers must ensure compliance with local regulatory frameworks before obtaining or handling 6-APB.

Storage and Handling

For laboratory environments, typical guidance includes:

• Cool, dry, light-protected storage
• Proper labeling and hazard communication
• Use of PPE (gloves, masks, goggles)
• Secure, access-controlled facility protocols

Why Researchers Study 6-APB

6-APB remains a relevant compound in the research community because it offers:

• A comparative model to well-established entactogenic compounds
• Insights into monoamine receptor interactions
• Opportunities for SAR exploration within benzofuran structures

These characteristics make it valuable in pharmacological, toxicological, and forensic research contexts.

6-APB research chemical

Benzofuran compounds

6-APB scientific analysis

Monoamine transporter study

6-APB SAR research

6-APB legal status

6-APB chemical properties